Radiation is used in most medical imaging procedures at low doses considered Researchers found in a new study, however, that these doses create DNA breaks that allow extra DNA sequences to integrate into the chromosomes of human cells. An article authored by Roland Kanaar, Alex Zelensky, and colleagues from Erasmus University Medical Center and Oncode Institute to be published in PLOS Genetics on 16th January provides these new insights into the human genome.
The scientists have known for a long time that exposing cells to high doses of ionizing radiation can lead to mutations by causing DNA strand breaks that let external segments into the cells. pieces of DNA are often left over from natural processes such as genomic DNA repair and viral infection in the nucleus. By irradiating human and mouse cells grown in the laboratory, the authors examined whether low doses of ionizing radiation had damaging side effects. Based on their counts of cells that had accepted foreign DNA, they found that low radiation doses, which are higher than the doses the researchers typically used for diagnostic procedures, were much more efficient at causing mutations than much larger doses.
In spite of the potentially worrying results in cell culture, the study’s authors say it is premature to generalize radiation’s effects on the body based on lab-grown cells. Using animal models will be necessary in the future in order to determine the full extent of the effects of low-dose radiation and to determine if the use of this form of radiation in medical imaging impacts In circumstances where the same phenomenon is also present inside the body, doctors will need to consider extraneous DNA levels, such as those resulting from a long-term viral infection, when considering the risks associated with a radiation therapy procedure. Radiobiological studies on the molecular level are generally focused on studies of high doses of ionizing radiation relevant to cancer treatment, but the effects of physiologically relevant doses of radiation on the cell are difficult to determine, according to the The discovery that mutagenic insertion of foreign DNA into cells’ genomes is sensitive to doses encountered during diagnostic procedures rather than therapeutic procedures provides a new simple and sensitive method of studying the consequences of DNA damage and reveals molecular genetic details of how cells respond to normal amounts.”