Researchers are interested in stem cells since they have the potential to be immortal in culture, which makes them a great asset to research on aging. A higher level of proteostasis regulates the quality of proteins, which is what controls immortality. An international team of researchers led by David Vilchez at the University of Cologne’s Cluster of Excellence CECAD has found a link between improved proteostasis and a higher level of immortalities in In the case of human embryonic stem cells, they are considered Since they do not age, they can grow and reproduce indefinitely, and they can form any type of tissue of any Because of this, they do not accumulate damage proteins such as those that contribute to diseases such as Alzheimer’s and Huntington’s disease. Due to this, they are especially useful in research on aging. Immortality may be attributed to the proteasome, which is a key node in the proteostasis network, and serves as a garbage disposal system.

In the proteasome system, the E3-ubiquitin ligases are of particular importance. Keeping our cells in a healthy state involves these enzymes marking proteins for degradation. The main author of the paper, Isabel Saez Martinez from CECAD, describes labeling them as a way to mark those that do not function. In this study, we screened more than 600 proteins systematically and selected 30 E3 ligases of particular interest. Once these 20 ligases were identified, we used the genome editing methodology CRISPR and RNAi approaches to silence the levels of E3 ligases. It was surprising to find that none of the stem cells showed any phenotype, they were acting normally. Isabel Saez Martinez speculates that this could be due to the redundancy of the proteins. In contrast, researchers found that a reduction in global proteolytic activity affects a wide range of embryonic stem cell properties, providing a link between the inevitability of immortality and up-regulation of Next, these proteases should be examined in relation to the aging process and the interactions they may have with their partners. Various neurodegenerative diseases are characterized by the accumulation of damaged proteins, which means better treatment of those diseases would be possible if stem cell function and proteostasis were better understood. It does not matter if we generate pluripotent stem cells from patients with those diseases because they do not contain those This gives us hope that those illnesses can be treated after more research has been conducted,